Effect of prolonged administration of caffeine during fracture repair progression in rats

Bone fracture is a complete or partial breakage of the bone structure. Fracture repair considered regenerative process whereby healing occurs through formation new tissue indiscernible from uninjured bone. reducing and realigning fractured ends together in other to achieve healing. Caffeine, 1, 3, 7-trimethylxanthine, an alkaloid present more than one hundred plant species. It used as stimulants it affects calcium mobilization body. may predispose fracture.Methodology; total 30 rats procured known breeder (University Maiduguri quarters) acclimatized for 14 days divided into 2 group A (15 rats), B rats). Group were administered caffeine orally at 500 mg/kg while given placebo which served control. Samples tibiae harvested on day 14, 28, 42 respectively. The samples decalcified using formic acid stained with H E (Hematoxylin Eosin) viewed under microscope X10, X40 X100 magnifications. results showed no significant difference between treated control 14. However, we observed histological 28 even though there was statistical student’s t test. (p>0.05) group.The finding shows that intake 5mg/kg above post delay repair.